NFL week 1 picks: Chargers beat Raiders; Bucs top Cowboys

Buffalo Bills tight end Dawson Knox (88) makes a catch for a touchdown during the first half of an NFL wild-card playoff game against the New England Patriots in Orchard Park, N.Y. on Jan. 15.
Pittsburgh Steelers quarterback Mitch Trubisky watches from the sideline during the second half of a preseason game against the Jacksonville Jaguars on Aug. 20 Jacksonville, Fla.
Indianapolis Colts quarterback Matt Ryan yells out the play during a preseason game against the Tampa Bay Buccaneers on Aug. 27 in Indianapolis.

Line: Colts by 7 1/2. O/U: 45 1/2.

The Colts should win this handily. Matt Ryan is a big upgrade from Carson Wentz. Texans will be able to run it OK, and Davis Mills has some promise, but they don’t have many weapons.

Miami Dolphins players wait to go out on the field before the start of a preseason game against the Las Vegas Raiders on Aug. 20 in Miami Gardens, Fla.

Line: Dolphins by 3 1/2. O/U: 46 1/2.

Dolphins don’t have any excuses. They’re pretty solid across the board if their quarterback can come through. Patriots have won with lackluster rosters before but playcalling change makes difference.

Baltimore Ravens quarterback Lamar Jackson (8) talks with linebacker Justin Houston (50) prior to a preseason game against the Tennessee Titans on Aug. 11 in Baltimore.
New Orleans Saints wide receiver Kirk Merritt warms up before a preseason game against the Chargers on Aug. 26 in New Orleans.

Line: Saints by 5 1/2. O/U: 42 1/2.

Not sure how much stock to put in Atlanta’s offense, and that Saints defense figures to be stifling. Left tackle is an issue for Saints, but Jameis Winston has weapons.

Detroit Lions running back Craig Reynolds rushes during a preseason game on Aug. 28 in Pittsburgh.

Line: Eagles by by 3 1/2. O/U: 48 1/2.

The Lions showed a lot of fight last season, and now they have some talent to go along with it. But Philadelphia is too good and deep in the trenches on both sides of the ball.

Jacksonville Jaguars quarterback Trevor Lawrence scrambles for yardage during the first half of a preseason game against the Pittsburgh Steelers on Aug. 20 in Jacksonville, Fla.
Chargers quarterback Justin Herbert hands off to running back Isaiah Spiller during warm ups before a preseason game on Aug. 20 at SoFi Stadium.
Minnesota Vikings running back Dalvin Cook takes part in joint drills with the San Francisco 49ers at the Vikings’ practice facility in Eagan, Minn. on Aug. 17.

Line: Packers by 1 1/2. O/U: 47 1/2.

Justin Jefferson, Dalvin Cook, Adam Thielen, Irv Smith … the Vikings have a full array of offensive options. Aaron Rodgers might be the best QB in the league but he needs to find his weapons.

Dallas Cowboys quarterback Dak Prescott warms up before a preseason game against the Chargers on Aug. 24 at SoFi Stadium.

The Buccaneers have issues along the offensive line, but their defense is healthy for the first time in ages. Dak Prescott is dangerous, yes, but he needs to find more targets than CeeDee Lamb.

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